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| <AnneRD>
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I was just given this information at my facility. It may help:
NCEP ISSUES MAJOR NEW CHOLESTEROL GUIDELINES > > The National Cholesterol Education Program (NCEP) today issued major > new > clinical practice guidelines on the prevention and management of high > cholesterol in adults. The guidelines are the first major update from > NCEP in nearly a decade. > > NCEP, which is coordinated by the National Heart, Lung, and Blood > Institute (NHLBI), develops new guidelines as warranted by research > advances. Earlier guidelines were issued in 1988 and 1993. An executive > summary of the new guidelines, the �Third Report of the NCEP Expert > Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol > in Adults,� also known as Adult Treatment Panel (ATP) III, appears in > the May 16, 2001, issue of the Journal of the American Medical > Association. > > Key changes in the new guidelines are: more aggressive > cholesterol-lowering treatment and better identification of those at > high risk for a heart attack; use of a lipoprotein profile as the first > test for high cholesterol; a new level at which low HDL (high-density > lipoprotein) becomes a major heart disease risk factor; a new set of > �Therapeutic Lifestyle Changes,� with more power to improve cholesterol > levels; a sharper focus on a cluster of heart disease risk factors > known > as �the metabolic syndrome;� and increased attention to the treatment > of > high triglycerides. > > The new guidelines are expected to substantially expand the number of > Americans being treated for high cholesterol, including raising the > number on dietary treatment from about 52 million to about 65 million > and increasing the number prescribed a cholesterol-lowering drug from > about 13 million to about 36 million. > > �Americans at high risk for a heart attack are too often not identified > and, so, don�t receive sufficiently aggressive treatment,� said NHLBI > Director Dr. Claude Lenfant. �Yet, studies show conclusively that > lowering the level of low-density lipoprotein, or LDL, the �bad > cholesterol,� can reduce the short-term risk for heart disease by as > much as 40 percent. Treatment may lower risk over the long-term-that > beyond 10 years-even more. That�s why, while the intensity of treatment > in ATP III is stepped up, its primary aim remains squarely on lowering > LDL.� > > According to ATP III, Americans at high risk for a heart attack include > those with heart disease or diabetes, and many of those with multiple > heart disease risk factors. The guidelines state that diabetes poses as > great a risk for having a heart attack in 10 years as heart disease > itself-and the threat from multiple risk factors can be equally great. > The guidelines recommend these persons be treated as intensively as > heart disease patients with lifestyle changes and medication. > > To better identify risk, the guidelines include a tool that predicts a > person�s chance of having a heart attack within 10 years. Based on > newly > analyzed data from the landmark, NHLBI-supported Framingham Heart > Study, > the �risk assessment tool� translates clinical conditions and lifestyle > factors into a single, easy-to-understand category of risk. The tool > calculates risk separately for men and women based on age, total > cholesterol, HDL (the �good� cholesterol), systolic blood pressure, > treatment for high blood pressure, and cigarette smoking. ATP III > recommends use of the tool for persons with two or more heart disease > risk factors. > > �The new guidelines will help doctors determine heart attack risk more > precisely than was possible before,� said Dr. Scott Grundy, ATP III > chairperson and director of the Center for Human Nutrition at the > University of Texas Southwestern Medical Center at Dallas. �That allows > treatment to be more individualized. We now know that > cholesterol-lowering treatment is more effective when its intensity > closely matches the level of risk.� > > �The ATP III approach looks at �overall� risk for a heart attack,� said > NCEP Coordinator Dr. James Cleeman, �which means in the short- and > long-term. That�s important because, although risk typically increases > with age, the foundation for heart disease is often laid in adolescence > and early adulthood. So Americans need to act now to prevent that > future > heart attack or heart disease itself. Every risk factor needs to be > treated.� > > > Cleeman advises Americans to check with their doctor to learn their > overall risk for a heart attack and what, if any, treatment is needed. > > > Other changes in the new guidelines include: > > Treating high cholesterol more aggressively for those with > diabetes. > > Besides their very high short-term risk for having a coronary > event, persons with Type 2 diabetes also have a particularly > high risk of dying from a heart attack. Type 2 diabetes, or > noninsulin-dependent diabetes mellitus, is the most common > form of the disease and affects more than 14 million > Americans. > A lipoprotein profile as the first test for high cholesterol. > > A lipoprotein profile measures levels of LDL, total > cholesterol, HDL, and triglycerides, another fatty substance > in the blood. The prior recommendation called for initial > screening with a test for only total cholesterol and HDL. The > guidelines advise healthy adults to have a lipoprotein > analysis once every 5 years. > A new level at which low HDL becomes a major risk factor for > heart disease. > > ATP III defines a low HDL as being less than 40 mg/dL. > Previously, a low HDL was less than 35 mg/dL. The change > reflects new findings about the significance of a low HDL, > and > the strong link between a low HDL and an increased risk of > heart disease. An HDL level of 60 mg/dL or more is considered > protective against heart disease. > Intensified use of nutrition, physical activity, and weight > control in the treatment of elevated blood cholesterol. ATP III > combines these steps into a new �Therapeutic Lifestyle Changes� > (TLC) treatment plan. > > ATP III recommends a more intense and effective eating plan > than that previously used. The new diet reflects changes in > Americans� eating habits, including a drop in saturated fat > and cholesterol consumption. The new TLC diet includes daily > intakes of less than 7 percent of calories from saturated fat > and less than 200 mg of dietary cholesterol. It also allows > up > to 35 percent of daily calories from total fat, provided most > is from unsaturated fat, which doesn�t raise cholesterol > levels. (A higher fat intake may be needed by some patients > with high triglycerides and/or a low HDL to keep their > triglycerides or HDL from worsening.) > > ATP III also encourages use of certain foods that contain > plant stanols and sterols, or are rich in soluble fiber, to > boost the diet�s LDL-lowering power. Plant stanols and > sterols > are included in certain margarines and salad dressings; foods > high in soluble fiber include cereal grains, beans, peas, > legumes, and many fruits and vegetables. > > Additionally, the guidelines stress the need for weight > control and physical activity, both of which improve various > heart disease risk factors. For instance, weight control > enhances LDL lowering and raises HDL, while physical activity > improves HDL and, for some, LDL. �TLC is the first line of > therapy for high cholesterol and, with the turbo-charge that > ATP III gives it, it will be significantly more effective in > lowering LDL than the previous lifestyle recommendations,� > said Cleeman. > Identifying a �metabolic syndrome� of risk factors linked to > insulin resistance, which often occur together and dramatically > increase the risk for coronary events. > > The syndrome includes factors such as too much abdominal fat > (indicated by too large a waist measurement), elevated blood > pressure, elevated triglycerides, and low HDL. Therapy for > the > syndrome emphasizes TLC, especially weight control and > physical activity. Insulin controls the body�s metabolism of > carbohydrates, fats, and protein. In insulin resistance, its > normal actions are impaired. �The metabolic syndrome has > emerged as being as strong a contributor to early heart > disease as cigarette smoking,� said Grundy. �In addition, the > insulin resistance that goes along with the syndrome is one > of > the underlying causes of Type 2 diabetes. It�s thus very > important to recognize the syndrome and treat it with > lifestyle changes.� > More aggressive treatment for elevated triglycerides. > > Recent studies indicate that an elevated triglyceride level > is > significantly linked to the degree of heart disease risk. The > new guidelines recommend treating even borderline-high > triglyceride levels. Therapy includes weight control and > physical activity and sometimes, for higher triglyceride > levels, medication. > Advising against the use of hormone replacement therapy (HRT) as > an alternative to cholesterol-lowering drugs. > > According to ATP III, studies have not shown that HRT reduces > the risk for major coronary events or deaths among > postmenopausal women who have heart disease. HRT also > increases the risk for thromboembolism and gallbladder > disease. In contrast, cholesterol-lowering drugs have been > found to reduce coronary events in women with or without > heart > disease. > > Founded in 1985, NCEP seeks to reduce the prevalence of high blood > cholesterol among Americans. It is a multidisciplinary coalition with a > Coordinating Committee comprised of representatives from more than 40 > major medical and health professional associations, voluntary health > organizations, community programs, and governmental agencies. > > The new guidelines were developed over 20 months by 27 panel members > and > consultants who are leading experts in heart disease, lipid measurement > and management, primary care medicine, nutrition, epidemiology, health > economics, and other areas. The guidelines were reviewed and approved > by > NCEP�s Coordinating Committee. NHLBI is part of the National Institutes > of Health, located in Bethesda, MD. > > To arrange an interview with Cleeman, contact the NHLBI Communications > Office at (301) 496-4236. Also available from the NHLBI Communications > Office is a b-roll with soundbites. There will be the following > satellite feeds of the b-roll: May 15, 2001, 2 p.m. to 2:15 p.m. > Eastern, Telstar 4, Transponder 6, DL 3820, C-Band; May 16, 2001, 1:15 > p.m. to 1:30 p.m. Eastern, Telstar 5, Transponder 16, DL 4020, C-Band. > > To interview Grundy, contact Amy Shields, University of Texas > Southwestern Medical Center�s Office of News and Publications, at (214) > 648-3404. > > The following ATP III and cholesterol-related materials can be found > online: > The guidelines� executive summary and �At A Glance� desk reference for > physicians > <http://www.nhlbi.nih.gov/guidelines/cholesterol/atp_iii.htm> > ; > an interactive version of the guidelines for PalmOS� devices < > http://hin.nhlbi.nih.gov/atpiii/atp3palm.htm>; > a patient brochure, �High Blood Cholesterol-What You Need To Know� < > http://www.nhlbi.nih.gov/health/public/heart/index.htm>; > a 10-year heart attack risk calculator < > http://hin.nhlbi.nih.gov/atpiii/calculator.asp?usertype=prof>; > and a �Live Healthier, Live Longer� Web site < > http://www.nhlbi.nih.gov/chd/index.htm> for patients and the public. > To get these items, go to the NHLBI home page < > http://www.nhlbi.nih.gov/index.htm> (at www.nhlbi.nih.gov) and click on > ATP III Cholesterol Guidelines under Highlights. > > > > |
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